Cannabidiol (CBD) Found to Reduce Seizure Frequency in Phase III Trial The oral administration of CBD (cannabidiol) reduces seizure frequency in children with intractable epilepsy, according to placebo-controlled, randomized trial data published in The New England Journal of Medicine. In this double-blind, placebo-controlled trial, they randomly assigned 120 children and young adults with the Dravet syndrome and drug-resistant seizures to …