Cannabidiol (CBD) Reduces Blood Pressure

According to clinical trial data published online in the Journal of Clinical Investigation. Investigators from the University of Nottingham in the United Kingdom assessed the effects of a single oral dose of 600 mg of CBD extract versus placebo in nine male subjects. Preclinical studies show CBD has numerous cardiovascular benefits, including a reduced blood pressure (BP) response to stress. …

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Cannabidiol Found to Reduce Seizure Frequency in New Trail

Cannabidiol (CBD) Found to Reduce Seizure Frequency in Phase III Trial The oral administration of CBD (cannabidiol) reduces seizure frequency in children with intractable epilepsy, according to placebo-controlled, randomized trial data published in The New England Journal of Medicine. In this double-blind, placebo-controlled trial, they randomly assigned 120 children and young adults with the Dravet syndrome and drug-resistant seizures to …

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Vanilloid Receptors

CBD directly interacts with various ion channels to confer a therapeutic effect. CBD, for example, binds to TRPV1 receptors, which also function as ion channels. TRPV1 is known to mediate pain perception, inflammation and body temperature. TRPV is the technical abbreviation for “transient receptor potential cation channel subfamily V.” TRPV1 is one of several dozen TRP (pronounced “trip”) receptor variants …

CBD as an allosteric modulator

Allosteric Modulator Australian scientists report that CBD acts as a “positive allosteric modulator” of the GABA-A receptor. In other words, CBD interacts with the GABA-A receptor in a way that enhances the receptor’s binding affinity for its principal endogenous agonist, gamma-Aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. The sedating effects of Valium …

Industrial Hemp Revival

Joy Beckerman, president of Hemp Ace International, a Seattle-based consulting firm, teaches a class for law students on “The Curious Legal Status of CBD and Industrial Hemp-Derived Cannabinoids.” An industrial hemp entrepreneur and advocate for the past 25 years, Beckerman recognizes that cannabidiol has played a key role in jump-starting the creation of new infrastructure for hemp’s vast oilseed and …

Anxiety, Depression and treating it with Cannabidiol

Anxiety and depression are two of the most common mental health concerns in the world today. In fact, the chances are fairly good that you, the reader, have dealt with (or will deal with) a clinically-diagnosable level of anxiety of depression at some point during your lifetime—whether it’s lasting or temporary. According to statistics released by the Anxiety and Depression …

Cardiovascular Issues and How CBD Could Help

Heart disease is—and has been for decades—the leading cause of death in the United States. As many as a quarter of the deaths in the country can be attributed to heart disease, particularly in the case of males. Often, those dealing with known heart conditions are given a directive to improve diet and exercise and are prescribed some sort of …

Tourette’s Syndrome and the Possible Cannabidiol Answer

When you hear the words “Tourette’s syndrome,” chances are you have a particular image in mind: a young child, perhaps thrashing about, swearing at his parents and saying unspeakable things in public. While it’s certainly the most famous and dramatic portrayal of the condition, Tourette’s syndrome can affect an individual of any age, and is usually more subdued, involving a …

Kick (cigarette) butt with CBD oil

“That’s it, I’m quitting for good!” Thousands have said it, have declared being finished with smoking cigarettes forever, but not all manage to pull through. The mere mention of quitting cigarettes can bring a sympathetic grimace to any face, as we all know that nicotine cravings are notoriously tough to beat. Fortunately for those seeking to kick the butt completely, …